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Related Experiment Videos

Mucoadhesive chitosan-coated liposomes: characteristics and stability.

J Filipović-Grcić1, N Skalko-Basnet, I Jalsenjak

  • 1Department of Pharmaceutics, Faculty of Pharmacy and Biochemistry, University of Zagreb, Croatia.

Journal of Microencapsulation
|February 24, 2001
PubMed
Summary

Chitosan coating enhances liposome stability and drug entrapment. This study shows chitosan-coated liposomes offer improved protection for entrapped substances in simulated gastric conditions.

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Area of Science:

  • Materials Science
  • Pharmaceutical Sciences
  • Biotechnology

Background:

  • Liposomes are versatile drug delivery systems.
  • Chitosan is a biocompatible polymer with mucoadhesive properties.
  • Improving liposome stability and drug loading is crucial for effective drug delivery.

Purpose of the Study:

  • To investigate the effect of chitosan coating on liposome characteristics.
  • To evaluate the impact of different chitosan types on liposome properties.
  • To assess the stability and drug entrapment efficiency of chitosan-coated liposomes.

Main Methods:

  • Liposomes containing FITC-dextran were prepared using the ethanol injection method.
  • Chitosan coating was achieved by mixing liposomes with chitosan solutions.

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  • Liposome size, morphology, entrapment efficiency, and stability in simulated gastric fluid were analyzed.

    • Main Results:

    • Chitosan coating increased liposome size to 300-330 nm, maintaining spherical morphology.
    • Entrapment efficiency increased to 60-65%, with medium molecular weight chitosan yielding the highest entrapment.
    • Chitosan-coated liposomes exhibited significantly enhanced stability in simulated gastric fluid compared to uncoated liposomes.

    Conclusions:

    • Chitosan coating effectively stabilizes liposomal structures.
    • Chitosan improves the protection of liposomally entrapped substances.
    • Medium molecular weight chitosan is optimal for enhancing entrapment efficiency in liposomes.