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Feeding problems in Silver-Russell syndrome

J Blissett1, G Harris, J Kirk

  • 1University of Birmingham, Edgbaston, UK. J.Blissett@bham.ac.uk

Insights

Children with Silver-Russell syndrome (SRS) face significant feeding problems like poor appetite and oral-motor issues. Interventions should focus on improving parent-child mealtime interactions and reducing parental anxiety.

Area of Science:

  • Pediatric Gastroenterology
  • Developmental Pediatrics
  • Genetics

Background:

  • Silver-Russell syndrome (SRS) is a rare genetic disorder characterized by intrauterine and postnatal growth restriction.
  • Feeding difficulties are frequently reported in children with SRS, but their prevalence and impact require further investigation.

Purpose of the Study:

  • To determine the prevalence and severity of feeding problems in children with SRS.
  • To compare feeding behaviors and parent-child interactions in children with SRS versus healthy controls.
  • To assess the nutritional intake in children with SRS experiencing feeding difficulties.

Main Methods:

  • A cohort of 32 children with SRS and 32 age- and sex-matched controls were evaluated using the Feeding Assessment Questionnaire.
  • Parent-child mealtime interactions were video-recorded in a subset of participants.
  • A 3-day weighed food diary was used to assess food intake.

Main Results:

  • Children with SRS exhibited significantly more feeding problems, including poor appetite, fussiness, slow feeding, and oral-motor dysfunction, compared to controls.
  • Despite feeding challenges, nutritional intake (kilocalories, protein, fat, carbohydrates) was not significantly affected.
  • Mealtime interactions were markedly more negative in SRS families than in control families.

Conclusions:

  • Feeding problems are prevalent and multifaceted in children with SRS, encompassing behavioral and oral-motor components.
  • Nutritional intake appears adequate despite reported feeding issues, suggesting a need to manage parental concerns.
  • Intervention strategies for SRS should prioritize reducing negative parent-child interactions and alleviating parental anxiety regarding feeding and growth.

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