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Related Experiment Videos

Gut mucosal immunostimulation by lactic acid bacteria.

E Vitiñi1, S Alvarez, M Medina

  • 1Cátedra Inmunología, Instituto de Microbiología, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán, Argentina.

Biocell : Official Journal of the Sociedades Latinoamericanas De Microscopia Electronica ... Et. Al
|February 24, 2001
PubMed
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Not all lactic acid bacteria (LAB) strains are effective oral adjuvants. Studies show LAB can boost IgA production and immune responses, but efficacy varies by strain, highlighting the need for careful selection.

Area of Science:

  • Immunology
  • Microbiology
  • Gastroenterology

Background:

  • Lactic acid bacteria (LAB) offer health benefits, but their role in activating the gut mucosal immune system and their adjuvant potential remain unclear.
  • The specific mechanisms and whether all LAB strains possess adjuvant properties are not fully understood.

Purpose of the Study:

  • To investigate the influence of oral administration of various LAB genera on the gut mucosal immune system.
  • To determine if different LAB strains stimulate specific, non-specific (inflammatory), or both immune responses.
  • To assess the immunoadjuvant capacity of selected LAB strains.

Main Methods:

  • Oral administration of diverse LAB genera including Lactobacillus casei, L. acidophilus, L. rhamnosus, L. delbrueckii subsp. bulgaricus, L. plantarum, Lactococcus lactis, and Streptococcus thermophilus.

Related Experiment Videos

  • Evaluation of stimulation of specific and non-specific immune responses.
  • Quantification of IgA-producing cells in the lamina propria and assessment of CD4+ and CD8+ T cell populations.

    • Main Results:

    • All tested LAB increased IgA-producing cells in the small intestine lamina propria in a dose-dependent manner.
    • IgA+ cell increase was not always linked to CD4+ T cell elevation, suggesting some LAB promote B cell activation only.
    • Most LAB increased inflammatory response cells, while CD8+ T cells generally decreased or remained unaffected, except for L. plantarum at low doses.

    Conclusions:

    • The immunoadjuvant capacity varies significantly among LAB strains, indicating that not all LAB can serve as effective oral adjuvants.
    • The beneficial effects of LAB cannot be generalized across genera or species; strain-specific properties are crucial.
    • Careful selection of LAB strains is essential for optimizing their use as gut mucosal adjuvants.