Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Immunogenetic markers in hemoblastosis].

Iu M Zaretskaia, E G Khamaganova, S M Aleshchenko

    Terapevticheskii Arkhiv
    |February 24, 2001
    PubMed
    Summary

    Specific HLA gene combinations indicate a general predisposition to blood cancers (hemoblastoses). Individual HLA gene profiles further refine risk for specific hematological malignancies like AML, ALL, CML, and LGM.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Parvovirus B19 infection in HIV-infected patients].

    Terapevticheskii arkhiv·2020
    Same author

    [Pure red cell aplasia of the bone marrow in combination with thymoma. A literature review and own data].

    Terapevticheskii arkhiv·2020
    Same author

    [Impact of radiotherapy and chemotherapy for malignancies of the head and neck on thyroidal function and structure].

    Problemy endokrinologii·2019
    Same author

    Coinheritance of HbD-Punjab/β+-thalassemia (IVSI+5 G-C) in patient with Gilbert's syndrome.

    Terapevticheskii arkhiv·2019
    Same author

    [Analysis of inpatient care for HIV-positive patients with malignant lymphomas and hepatitis over 5 years (2011-2015) at the A.S.Loginov Moscow Clinical Research Center, Moscow Healthcare Department].

    Terapevticheskii arkhiv·2017
    Same author

    [All-Russian Consensus on Diagnosis and Treatment of Celiac Disease in Children and Adults].

    Terapevticheskii arkhiv·2017

    Area of Science:

    • Immunogenetics
    • Hematology
    • Oncology

    Context:

    • Investigating the role of Human Leukocyte Antigen (HLA) genes in hematological malignancies.
    • Understanding the genetic basis of predisposition and resistance to blood cancers.

    Purpose:

    • To identify general and specific HLA gene associations with the risk of developing hemoblastoses.
    • To explore HLA gene markers for predisposition to specific hematological diseases such as AML, ALL, CML, and LGM.

    Summary:

    • Analysis of HLA class I and II genes in patients with AML, ALL, CML, LGM, and healthy donors revealed specific HLA types associated with increased risk.
    • HLA specificities Cw7, DRB1*11, and B5 were found to be generally associated with hemopoiesis predisposition to malignancy.
    • Individual HLA gene combinations were identified as markers for specific hemoblastoses, while DRB1*07 showed a general preventive role.

    Impact:

    • Provides insights into the genetic susceptibility to blood cancers.
    • Highlights potential HLA-based biomarkers for early detection and risk stratification of hemoblastoses.
    • Informs future research on targeted immunogenetic therapies for hematological malignancies.

    Related Experiment Videos