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A Decellularization Methodology for the Production of a Natural Acellular Intestinal Matrix
Published on: October 7, 2013
An alternative to synthetic aortic grafts using jejunum
S E Marshall1, S M Tweedt, C H Greene
1Department of Biomedical Sciences, Philadelphia College of Osteopathic Medicine, Pennsylvania 19131, USA.
Summary
Porcine small intestinal submucosa (SIS) allografts show promise as arterial grafts. This study demonstrated successful reendothelialization and neovascularization in a porcine model, suggesting SIS may overcome synthetic graft complications.
Area of Science:
- Biomaterials Science
- Vascular Surgery
- Regenerative Medicine
Background:
- Synthetic arterial grafts risk complications like infection and rejection.
- Porcine small intestinal submucosa (SIS) presents a potential alternative biomaterial.
- SIS allografts may offer an effective solution with fewer adverse effects.
Purpose of the Study:
- To evaluate the performance of porcine small intestinal submucosa (SIS) as an arterial allo-patch graft.
- To assess reendothelialization and neovascularization of SIS grafts in a porcine model.
- To provide data for comparing SIS graft hemodynamics to human physiology.
Main Methods:
- SIS graft material was prepared from porcine jejunum.
- Grafts were implanted as allo-patches in the infrarenal aorta of a porcine model.
- Grafts were harvested on postoperative day 28 for microscopic examination.
Main Results:
- Microscopic examination confirmed successful reendothelialization of the SIS grafts.
- Evidence of neovascularization within the graft material was observed.
- The porcine model allowed for hemodynamic comparisons relevant to human physiology.
Conclusions:
- Porcine small intestinal submucosa (SIS) demonstrates potential as a viable arterial graft material.
- SIS allografts facilitated host tissue integration, including reendothelialization and neovascularization.
- Further research into SIS grafts could lead to improved treatments for arterial repair.
