Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lymphangioleiomyomatosis.

J Kelly1, J Moss

  • 1Pulmonary-Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

The American Journal of the Medical Sciences
|February 24, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Screening for proximal deep vein thrombosis after acute ischemic stroke: a prospective study using clinical factors and plasma D-dimers.

Journal of thrombosis and haemostasis : JTH·2005
Same author

Identification of selenomethionine in selenized yeast using two-dimensional liquid chromatography-mass spectrometry based proteomic analysis.

The Analyst·2004
Same author

Electrical and neurotransmitter activity of mature neurons derived from mouse embryonic stem cells by Sox-1 lineage selection and directed differentiation.

The European journal of neuroscience·2004
Same author

A follow-up of repair of ruptured uterus in Ethiopia.

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology·2004
Same author

Vesico-vaginal and recto-vaginal fistulae.

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology·2004
Same author

The diagnosis of borderline iron deficiency: results of a therapeutic trial.

Archives of disease in childhood·2004
Same journal

Providers' Perspectives on Hospital-Based Tobacco Treatment Efforts.

The American journal of the medical sciences·2026
Same journal

In Memoriam: Maurice A. Mufson, MD, MACP.

The American journal of the medical sciences·2026
Same journal

Outcomes of Acute Myeloid Leukemia Patients Admitted to the Intensive Care Unit within 100 days of Allogeneic Hematopoietic Stem Cell Transplantation.

The American journal of the medical sciences·2026
Same journal

Association Between Reverse Triiodothyronine and Cardiac Complications in Patients with Uncontrolled Graves' Disease.

The American journal of the medical sciences·2026
Same journal

Chlorthalidone vs. hydrochlorothiazide in hypertension management: Lessons for guiding clinical practice.

The American journal of the medical sciences·2026
Same journal

The impact of COVID-19 on alcohol-associated hepatitis and alcohol-associated cirrhosis.

The American journal of the medical sciences·2026
See all related articles

Lymphangioleiomyomatosis (LAM) is a rare smooth muscle disorder primarily affecting women, causing lung and lymphatic abnormalities. Current hormonal therapies show potential for a more favorable clinical course in recent studies.

Area of Science:

  • Pulmonary Medicine
  • Rare Diseases
  • Oncology

Background:

  • Lymphangioleiomyomatosis (LAM) is a rare, sporadic neoplastic disorder affecting women of reproductive age.
  • It is characterized by abnormal proliferation of smooth muscle-like cells in the lungs, lymphatics, and other organs.
  • LAM presents with symptoms such as dyspnea, pneumothorax, and chylous effusions.

Purpose of the Study:

  • To describe the clinical characteristics and management of Lymphangioleiomyomatosis (LAM).
  • To review the current understanding of LAM pathogenesis and treatment strategies.
  • To evaluate the efficacy of hormonal therapies in patients with LAM.

Main Methods:

  • Review of existing literature on LAM.
  • Analysis of clinical data from LAM patient cohorts.

Related Experiment Videos

  • Microscopic examination of affected tissues.

    • Main Results:

    • LAM involves abnormal smooth muscle proliferation in the lungs and lymphatic system.
    • Associated conditions include angiomyolipomas and chylous ascites.
    • Hormonal therapies are the primary treatment approach, with recent studies suggesting improved outcomes.

    Conclusions:

    • Lymphangioleiomyomatosis (LAM) is a complex disease requiring multidisciplinary management.
    • Further research is needed to establish definitive therapies and understand the underlying mechanisms of LAM.
    • While hormonal manipulation is common, its efficacy requires further validation.