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[D-dimer in the year 2000: current data and new perspectives].

D Prisco1, E Antonucci, R Marcucci

  • 1Centro di Riferimento Regionale per la Trombosi, Dipartimento Area Critica Medico-Chirurgica, Sezione di Clinica Medica Generale e Cardiologia, Università degli Studi di Firenze. d.prisco@dfc.unifi.it

Annali Italiani Di Medicina Interna : Organo Ufficiale Della Societa Italiana Di Medicina Interna
|February 24, 2001
PubMed
Summary

D-dimer testing is valuable for ruling out deep vein thrombosis and pulmonary embolism. While it shows promise in predicting atherothrombosis risk, further research is needed for arterial event prediction.

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Area of Science:

  • Biochemistry
  • Hematology
  • Vascular Medicine

Background:

  • D-dimer is a fibrin degradation product.
  • It is highly sensitive for venous thromboembolic disease.
  • Current use focuses on negative predictive value for DVT and PE.

Purpose of the Study:

  • To review the clinical utility of D-dimer.
  • To explore its role in venous and arterial thrombosis.
  • To assess its predictive value for atherothrombotic complications.

Main Methods:

  • Literature review of D-dimer studies.
  • Analysis of diagnostic strategies combining clinical assessment, imaging, and D-dimer.
  • Evaluation of D-dimer's association with coronary artery disease risk.

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Main Results:

  • D-dimer has high sensitivity and moderate specificity for VTE.
  • An integrated diagnostic strategy is recommended for DVT/PE.
  • Elevated D-dimer correlates with increased risk of coronary artery disease.
  • D-dimer may indicate a systemic prothrombotic state.

Conclusions:

  • D-dimer is crucial for excluding VTE but requires integrated diagnostic approaches.
  • D-dimer shows potential in predicting atherothrombosis risk.
  • Further studies are necessary to determine its clinical value in preventing arterial thrombotic events.