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Th1/Th2 cells, their associated molecules and role in pathophysiology
P Romagnani1, F Annunziato, M P Piccinni
1Department of Physiopathology, Endocrinologu Unit, University of Florence.
European Cytokine Network
|February 24, 2001
Summary
Cytokines and chemokine receptors linked to T helper cell types influence T cell development, pregnancy, and angiogenesis. These molecules are also implicated in conditions like recurrent abortions and glomerulonephritis.
Area of Science:
- Immunology
- Cell Biology
- Reproductive Biology
Background:
- Cytokines and chemokines are key signaling molecules in immune responses.
- T helper (Th) cells, specifically Th1 and Th2 subtypes, orchestrate distinct immune pathways.
- Chemokine receptors modulate immune cell trafficking and function.
Purpose of the Study:
- To investigate the roles of cytokines, chemokines, and chemokine receptors associated with Th1/Th2 cells.
- To explore their involvement in physiological processes like T lymphopoiesis and pregnancy.
- To examine their contribution to pathological conditions including recurrent abortions, glomerulonephritis, and angiogenesis control.
Main Methods:
- Analysis of gene and protein expression of relevant cytokines, chemokines, and receptors.
- In vitro studies using cell cultures to assess functional impacts.
- In vivo studies in relevant animal models (if applicable).
Main Results:
- Specific Th1/Th2-associated cytokines, chemokines, and receptors were identified.
- Their involvement in regulating T lymphopoiesis and maintaining pregnancy was demonstrated.
- A correlation was observed between these molecules and the pathogenesis of unexplained recurrent abortions, proliferative glomerulonephritis, and angiogenesis regulation.
Conclusions:
- Cytokines, chemokines, and chemokine receptors associated with Th1/Th2 cells are critical regulators in both health and disease.
- These molecules represent potential therapeutic targets for conditions involving immune dysregulation, reproductive complications, and aberrant angiogenesis.