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Improved bone regeneration and root coverage using a resorbable membrane with physically assisted cell migration and

J R Dodge1, H Greenwell, C Drisko

  • 1School of Dentistry, University of Louisville, 501 South Preston, Room 236, Louisville, Kentucky 40292, USA.

The International Journal of Periodontics & Restorative Dentistry
|February 24, 2001
PubMed
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Guided tissue regeneration with a polylactide membrane and bone graft achieved superior root coverage and bone fill for buccal recession defects compared to membrane alone.

Area of Science:

  • Periodontology
  • Regenerative Dentistry
  • Biomaterials

Background:

  • Buccal recession defects pose challenges in periodontal therapy.
  • Guided tissue regeneration (GTR) principles are utilized for root coverage and bone regeneration.
  • Resorbable membranes and bone grafts are key components in GTR procedures.

Purpose of the Study:

  • To compare the effectiveness of a polylactide resorbable membrane (Guidor) versus a combination of polylactide membrane, polyglactin mesh (Vicryl), and demineralized freeze-dried bone allograft (DFDBA) for treating Miller Class I or II buccal recession defects.
  • To evaluate soft tissue root coverage and hard tissue regeneration in treated defects.

Main Methods:

  • Twelve patients with significant buccal recession defects (> or = 3.0 mm) were enrolled.

Related Experiment Videos

  • Two treatment groups: GA sites (polylactide membrane only) and GVB sites (polylactide membrane + Vicryl mesh + DFDBA).
  • Patients were followed for 12 months post-treatment.

    • Main Results:

    • The GVB sites demonstrated a mean soft tissue root coverage of 90%, compared to 78% for GA sites.
    • Mean osseous dehiscence area coverage with hard tissue was 75% for GVB sites and 30% for GA sites.
    • The combination therapy (GVB) showed significantly better outcomes in both soft tissue coverage and bone regeneration.

    Conclusions:

    • The combination of a polylactide membrane, polyglactin mesh, and DFDBA is more effective than a polylactide membrane alone for treating buccal recession defects.
    • This enhanced GTR approach promotes superior root coverage and bone regeneration.
    • The findings support the use of composite biomaterials in regenerative periodontal therapy.