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Related Experiment Videos

Recurrent aphthous stomatitis.

J A Ship1, E M Chavez, P A Doerr

  • 1Department of Oral Medicine, Pathology, Oncology, University of Michigan, School of Dentistry, Ann Arbor, Michigan 48109-1078, USA. jship@umich.edu

Quintessence International (Berlin, Germany : 1985)
|February 24, 2001
PubMed
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Recurrent aphthous ulceration (RAS) is the most common oral mucosal disease. While its exact cause remains unknown, research explores various local, systemic, genetic, immunologic, and infectious factors.

Area of Science:

  • Oral Medicine
  • Immunology
  • Epidemiology

Background:

  • Recurrent aphthous ulceration (RAS), historically termed 'aphthai', is a prevalent oral mucosal disease.
  • Despite extensive research into its causes, including local, systemic, genetic, immunologic, and infectious factors, a principal etiology is yet to be identified.

Purpose of the Study:

  • To review the current understanding of the etiology and epidemiology of recurrent aphthous ulceration (RAS).

Main Methods:

  • Literature review of studies investigating the causes and prevalence of RAS.
  • Analysis of epidemiological data from diverse populations.

Main Results:

  • RAS affects 2% to 50% of the general population, with estimates typically between 5% and 25%.

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  • Higher prevalence (50%-60%) observed in specific groups like medical and dental students.
  • Peak onset is between ages 10-19, with potential persistence throughout life, irrespective of demographic factors.

    • Conclusions:

    • RAS is a common oral condition with multifactorial potential causes.
    • Understanding its epidemiology is crucial for public health and clinical management.