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Updated: Aug 12, 2026

Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice
Published on: January 16, 2015
Estimation of electron absorbed fractions in the extrathoracic airways
H M Moussa1, K F Eckerman, L W Townsend
1University of Tennessee, Department of Nuclear Engineering, Knoxville 37996, USA. hmoussa@utk.edu
Abstract:
Dose calculations using the respiratory tract model presented in Publication 66 of the International Commission on Radiological Protection (ICRP) frequently predict that the basal cells of the anterior portion of the nose, the extrathoracic region ET1 of the model, are the most highly irradiated tissue of the body. The dose to the basal cells is averaged over a layer of tissue 10 microm thick located at a depth of 40 microm into the airway. Reported here are the results of a series of absorbed fraction calculations undertaken to compare with values tabulated in ICRP Publication 66. The Monte Carlo code MCNP4B and the geometric model of the ET1 region specified in Publication 66 were used in the calculations. Although some calculated differences are evident between the two sets of absorbed fractions, typically less than 20%, the calculations confirm that the electron absorbed fractions tabulated in Publication 66 are not responsible for the high estimates of the ET1 dose.

