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Related Experiment Videos

Mycoses in the transplanted patient.

M O Dictar1, E Maiolo, B Alexander

  • 1Servicio Infectología y Microbiología Clínica, Instituto A. Fleming, Buenos Aires, Argentina. mdictar@yahoo.com

Medical Mycology
|February 24, 2001
PubMed
Summary

Invasive fungal infections (IFIs) are a significant risk for transplant recipients. Stratifying patients by risk is crucial for effective prophylaxis and treatment strategies against candidiasis and aspergillosis.

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Area of Science:

  • Infectious Diseases
  • Transplantation Medicine
  • Mycology

Background:

  • Invasive fungal infections (IFIs) pose a growing threat, particularly to transplant recipients due to immunosuppression.
  • Solid organ transplant recipients (SOTRs) and bone marrow transplant (BMT) patients exhibit varying prevalence rates of IFIs (5-50%).
  • Candida and Aspergillus species are the predominant pathogens, causing over 80% of IFIs in these populations.

Purpose of the Study:

  • To provide an update on recent advances in laboratory diagnosis of candidiasis and aspergillosis in transplant patients.
  • To present findings from multicenter studies on IFIs in SOTR and BMT patients in Argentina.
  • To emphasize the need for improved diagnostic methods for IFIs.

Main Methods:

  • Retrospective and descriptive multicenter studies were conducted.

Related Experiment Videos

  • Analysis of IFIs in 1,861 SOTR patients across four centers.
  • Analysis of IFIs in 2,066 BMT patients from all 12 BMT centers in Argentina.
  • Main Results:

    • IFI prevalence varies significantly among different transplant types.
    • Candida and Aspergillus species are the most common fungal pathogens.
    • Multicenter data from Argentina provide insights into IFI epidemiology in SOTR and BMT patients.

    Conclusions:

    • Transplant recipients are not a homogenous group regarding IFI risk.
    • Stratification of patients based on individual risk degrees is essential.
    • Tailored prophylaxis and treatment strategies are necessary for optimal patient outcomes.