Magnesium in human semen: possible role in premature ejaculation

Area of Science:

• Reproductive biology
• Human physiology
• Men's health

Background:

• Magnesium is vital for numerous biological processes.
• Higher magnesium concentrations are observed in seminal plasma compared to serum.
• The specific role of magnesium in human semen remains unclear.

Purpose of the Study:

• To investigate the association between premature ejaculation and seminal magnesium levels.
• To explore the relationship between seminal plasma mineral concentrations and male ejaculatory function.

Main Methods:

• Atomic absorption spectrophotometry was used to measure magnesium, zinc, copper, and selenium levels.
• Analysis was performed on serum and seminal plasma samples from three groups of men: normal parameters, oligoasthenozoospermia, and premature ejaculation.
• Hormonal profiles and body mass index (BMI) were also assessed.

Main Results:

• All measured elements (magnesium, zinc, copper, selenium) were within normal ranges in both serum and seminal plasma across all groups.
• Men diagnosed with premature ejaculation exhibited significantly lower levels of magnesium in their seminal plasma.
• No significant association was found between premature ejaculation and hormonal profiles or BMI.

Conclusions:

• Reduced seminal magnesium levels may contribute to premature ejaculation.
• Potential mechanisms include magnesium's influence on vasoconstriction, intracellular calcium, and nitric oxide pathways.
• Further research is recommended to elucidate magnesium's role in male reproductive physiology, particularly concerning premature ejaculation and semen transport.