Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cytokine delivery and tissue engineering.

S J Lee1

  • 1Department of Pharmacy, College of Pharmacy, Ewha Womans University, Seoul, Korea. sjlee@ewha.ac.kr

Yonsei Medical Journal
|February 24, 2001
PubMed
Summary

This review explores using growth factors in tissue engineering scaffolds to improve healing. Incorporating these bioactive factors into devices extends their activity for better wound repair.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevalence of endoscopic reflux esophagitis among Koreans.

Journal of gastroenterology and hepatology·2001
Same author

Prognostic factors for early severe pulmonary complications after hematopoietic stem cell transplantation.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation·2001
Same author

Capsaicin inhibits the voltage-operated calcium channels intracellularly in the antral circular myocytes of guinea-pig stomach.

Life sciences·2001
Same author

Cloning and characterization of tissue inhibitor of metalloproteinase-3 (TIMP-3) from shark, Scyliorhinus torazame.

Biochimica et biophysica acta·2001
Same author

Evidence of New States Decaying into Xi(*)(c)pi.

Physical review letters·2001
Same author

Observation of B --> phiK and B --> phiK*.

Physical review letters·2001

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Cell Signaling

Background:

  • Tissue engineering shows promise for skin, cartilage, and bone regeneration.
  • Bioactive factors, like growth factors, are crucial for modulating cellular activities in tissue repair.
  • Growth factors have short biological half-lives, limiting their therapeutic efficacy.

Purpose of the Study:

  • To review the application of growth factor delivery systems in tissue engineering.
  • To highlight strategies for extending growth factor activity and achieving controlled release.
  • To discuss the role of tissue-engineered devices in facilitating wound healing and tissue repair.

Main Methods:

  • Review of literature on growth factor incorporation into polymeric scaffolds.
  • Analysis of strategies for controlled release of bioactive factors.
  • Examination of case studies demonstrating growth factor delivery for tissue repair.

Main Results:

  • Incorporating growth factors into polymeric devices extends their biological activity.
  • Controlled release systems enhance the therapeutic potential of growth factors.
  • Tissue-engineered devices can effectively deliver growth factors to promote healing.

Conclusions:

  • Growth factor delivery from engineered devices is a viable strategy for tissue regeneration.
  • Optimized delivery systems can overcome the limitations of short growth factor half-lives.
  • This approach holds significant potential for advancing wound healing and tissue repair applications.

Related Experiment Videos