Biodegradable poly (lactic acid) microspheres for drug delivery systems

Area of Science:

• Biomaterials Science
• Pharmaceutical Sciences
• Polymer Chemistry

Background:

• Conventional drug delivery systems (DDS) often face challenges in maximizing bioavailability and minimizing side effects.
• Biodegradable polymers, such as poly (lactic acid) (PLA) and poly (glycolic acid) (PGA), and their copolymers (PLGA), are increasingly explored for advanced DDS.
• Controlled or sustained drug release is a key strategy to improve therapeutic outcomes.

Purpose of the Study:

• To review the development and application of biodegradable microspheres for drug delivery.
• To evaluate the potential of PLA and PLGA-based microspheres for controlled and sustained drug release.
• To highlight the advantages of these novel DDS over conventional dosage forms.

Main Methods:

• Utilizing biodegradable polymers, specifically poly (lactic acid) (PLA) and poly (lactic-co-glycolic acid) (PLGA).
• Fabricating microcapsules and microspheres for the controlled release of bio-active agents.
• Reviewing a collaborative work program focused on DDS using these biodegradable microspheres.

Main Results:

• Biodegradable microspheres made from PLA and PLGA enable controlled and sustained drug release.
• These injectable microspheres offer pre-programmed durations of action.
• The use of these advanced DDS can lead to improved drug bioavailability and reduced side effects.

Conclusions:

• Biodegradable microspheres based on PLA and PLGA represent a promising approach for advanced drug delivery systems.
• These systems offer significant advantages over conventional drug formulations.
• Further development in this area holds potential for enhanced patient therapy.