Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Parkinson's disease, side affected and depression].

M Serrano-Dueñas1

  • 1Servicio de Neurología, Hospital Carlos Andrade Marín (Instituto Ecuatoriano de Seguridad Social) y Facultad de Medicina de la Pontificia Universidad Católica del Ecuador, Quito, Ecuador. serranom@pi.pro.ec

Revista De Neurologia
|February 24, 2001
PubMed
Summary

Parkinson's disease patients with dominant side involvement show higher depression scores. This suggests depression in Parkinson's may originate in the dominant hemisphere, irrespective of disease stage or L-dopa treatment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Delayed tension pneumoperitoneum after colonoscopy.

Medicina intensiva·2017
Same author

Dementia associated with Parkinson's disease: applying the Movement Disorder Society Task Force criteria.

Parkinsonism & related disorders·2011
Same author

High altitude headache. A prospective study of its clinical characteristics.

Cephalalgia : an international journal of headache·2005
Same author

Fluoxetine-induced tremor: clinical features in 21 patients.

Parkinsonism & related disorders·2004
Same author

[Sialorrhea in patients with Parkinson. A six year prospective study].

Revista de neurologia·2003
Same author

[Clonidine versus propranolol in the treatment of essential tremor. A double-blind trial with a one-year follow-up].

Neurologia (Barcelona, Spain)·2003

Area of Science:

  • Neurology
  • Neuroscience
  • Psychiatry

Background:

  • Depression is frequently observed in Parkinson's disease (PD).
  • Depression in PD is not correlated with disease stage or L-dopa treatment response.
  • Prior research suggests a potential link between right-sided Parkinsonism and increased depression.

Purpose of the Study:

  • To investigate if primary affection of the dominant side in Parkinson's disease correlates with higher depression levels.
  • To assess if dominant side involvement is associated with greater decline in Activities of Daily Living (ADLs) and motor function (UPDRSm).

Main Methods:

  • 63 patients with early-stage Parkinsonism (Hoehn and Yahr stage 1-1.5) were studied.
  • Patients were divided into L-dopa treated (Dopa group) and newly diagnosed (Naive group).

Related Experiment Videos

  • Evaluations included the Hamilton Depression Rating Scale, UPDRSm, and ADLs scale, analyzed using Wilcoxon's test (p < 0.01).

    • Main Results:

    • Patients with dominant side affected exhibited significantly higher depression scores in both groups (p < 0.001).
    • No significant differences were found in UPDRSm or ADLs scores between groups based on dominant side involvement.

    Conclusions:

    • Primary affection of the dominant side in Parkinson's disease is linked to increased depression.
    • Findings suggest that depression in Parkinson's disease may originate in the dominant hemisphere.