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[Paraneoplastic syndromes with peripheral nerve involvement].

M R Alvira-Duplá1, E Mayayo-Artal

  • 1Sección de Neurología, Servicio de Medicina Interna, Hospital Universitari Joan XXIII, Tarragona, España.

Revista De Neurologia
|February 24, 2001
PubMed
Summary

Paraneoplastic neurological disorders can affect the peripheral nervous system, often preceding tumor diagnosis. Autoimmune responses targeting nerves, like anti-Hu antibodies, suggest a paraneoplastic origin.

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Area of Science:

  • Neurology
  • Oncology

Background:

  • Paraneoplastic complications can manifest in the peripheral nervous system.
  • These neurological issues may appear before the primary tumor is clinically detected.

Purpose of the Study:

  • To review paraneoplastic complications affecting the peripheral nervous system.

Main Methods:

  • Review of tumor types (secretory carcinomas, lymphomas) associated with peripheral nerve involvement.
  • Classification of neuropathies based on clinical features: sensory, motor, senso-motor, autonomic, mononeuritis, and neuromyotonia.

Main Results:

  • Peripheral nerve involvement can precede tumor diagnosis.
  • Neuropathies may present as isolated or generalized nervous system disorders.

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Conclusions:

  • Presence of anti-Hu antibodies suggests a paraneoplastic origin.
  • Antibodies targeting voltage-dependent potassium channels are indicative of paraneoplastic peripheral nervous system disorders.