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Related Experiment Videos

Upcoming therapies for heart failure.

T X O'Brien1, A M Brown

  • 1Cardiology Section of the Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina, Ralph H. Johnson Veterans Administration Medical Center, Charleston, South Carolina, USA.

Clinical Cornerstone
|February 24, 2001
PubMed
Summary

Successfully treating congestive heart failure (CHF) neurohormonal activation relies on large clinical trials. New agents and devices targeting other CHF pathways are in development for future therapies.

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Area of Science:

  • Cardiovascular Science
  • Translational Medicine

Background:

  • Maladaptive neurohormonal activation is a key factor in congestive heart failure (CHF).
  • Previous success in treating CHF neurohormonal activation stemmed from rigorous clinical validation of basic science findings.

Purpose of the Study:

  • To review the evolution of CHF therapy targeting neurohormonal and cytokine pathways.
  • To highlight emerging novel agents and devices for CHF management.

Main Methods:

  • Review of basic cardiovascular science findings.
  • Analysis of outcomes from large-scale, well-controlled clinical trials.
  • Assessment of agents and devices in advanced clinical development.

Main Results:

  • Basic science discoveries regarding neurohormonal activation in CHF have been validated or refuted by clinical trials.

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  • Novel therapeutic strategies targeting additional pathways in CHF are progressing through clinical development.

    • Conclusions:

    • The successful treatment paradigm for CHF neurohormonal activation provides a foundation for new therapeutic approaches.
    • Emerging agents and devices targeting novel pathways are expected to significantly impact future CHF therapy.