[Activity of malondialdehyde in rat plasma after H2 histamine receptor blockade]

The study evaluates the effect of cimetidine (C), ranitidine (R) and famotidine (F) on the level of the plasma malondialdehyde (MDA). The tested drugs were given intraperitoneally to the male Wistar rats twice a day, during 6 weeks' period, in two doses. CI--2.85 mg/kg body weight (b.w.), R1--0.71 mg/kg b.w., F1--0.28 mg/kg b.w. The second doses (C2, R2, F2) were 10 times higher than C1, R1, F1. At the end of the 6th week of the experiment half of the animals were terminated. The remaining rats were kept for the next 6 weeks without any medications and were killed at the end of 12th week of the experiment. Blood was taken from still beating heart and centrifuged. The level of the MDA was determined from the plasma and compared to the 1 mg of the blood protein. None of administered H2 blockers changed the malondialdehyde level in serum of the experimental rats.