QT dispersion in single coronary artery disease: is there a relation between QT dispersion and diseased coronary

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Published on: August 28, 2018

H Tikiz1, T Terzi, Y Balbay

  • 1Department of Cardiology at Türkiye Yüksek Ihtisas Hospital, Ankara, Turkey.

Angiology
|February 24, 2001
PubMed

Insights

Patients with single-vessel coronary artery disease exhibit higher baseline QT dispersion (QTD). Exercise stress testing revealed increased QTD, suggesting localized ischemia severity impacts inducible QTD more than disease extent.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Ischemic Heart Disease

Background:

  • QT dispersion (QTD) increases during myocardial ischemia and infarction.
  • Limited data exists on the relationship between coronary artery disease (CAD), lesion localization, and QTD.

Purpose of the Study:

  • To investigate the association between QTD and diseased coronary artery or lesion localization during exercise stress testing.
  • To analyze QTD in patients with single-vessel CAD without prior myocardial infarction.

Main Methods:

  • 119 patients with single-vessel CAD and 53 controls underwent exercise stress testing (modified Bruce protocol).
  • QT interval parameters were measured at rest and during the recovery period (rec-2).

Main Results:

  • Baseline QTD was higher in all single-vessel CAD groups versus controls.
  • Corrected QTD at rec-2 was significantly higher in patients with left anterior descending, circumflex, or right coronary artery disease.
  • No significant correlation was found between QTD and the specific diseased coronary artery or lesion localization (proximal vs. distal).

Conclusions:

  • Patients with single-vessel CAD show elevated baseline QTD, which increases with exercise.
  • Localized ischemia severity, rather than the extent of CAD, appears to be a greater determinant of inducible QTD.

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