Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Review: reticuloruminal motility--a pharmacological target with a difference?

B F Leek1

  • 1Department of Veterinary Physiology & Biochemistry, University College Dublin, Veterinary College, Ireland.

The Veterinary Quarterly
|February 24, 2001
PubMed
Summary

Investigating sheep reticuloruminal motility, this study reveals how bacterial endotoxins and adrenergic signals impact gastric centers and smooth muscle. Findings clarify neural pathways controlling digestion and rumination.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adrenergic influence of uterine muscle contractions stimulated by a glycoside from the root of Dalbergia saxatilis.

Indian journal of experimental biology·2000
Same author

Ultrastructural changes in the nerve fiber population of anastomosed vagal and spinal accessory nerves in the sheep.

The Anatomical record·1997
Same author

The effects of intracoeliac injections of alpha-adrenergic agonists and veratridine on reticuloruminal motility and the evocation of rumination in sheep.

Zentralblatt fur Veterinarmedizin. Reihe A·1995
Same author

Mechanoreceptors in the crop of the domestic fowl.

Poultry science·1994
Same author

The effects of experimentally induced fever on the estimated blood flow to and oxygen utilization by the liver and the viscera drained by the portal vein in sheep.

Veterinary research communications·1991
Same author

Rumination in pregnant ewes.

Zentralblatt fur Veterinarmedizin. Reihe A·1990

Area of Science:

  • Veterinary Physiology
  • Neurogastroenterology
  • Ruminant Digestive Function

Background:

  • Ruminant reticuloruminal motility is crucial for digestion and influenced by complex neural pathways.
  • Understanding the central and peripheral regulation of gastric centers is essential for animal health.

Purpose of the Study:

  • To investigate vagal influences on hindbrain gastric centers regulating reticuloruminal motility in sheep.
  • To elucidate the effects of bacterial endotoxins and adrenergic agents on reticuloruminal function.

Main Methods:

  • Electrophysiological single-fiber recordings in anesthetized sheep.
  • Pharmacological interventions via close-arterial injections (carotid and coeliac arteries).
  • Studies in conscious, surgically prepared sheep to assess indirect effects.

Related Experiment Videos

Main Results:

  • Escherichia coli lipopolysaccharide induced smooth muscle relaxation and gastric center depression, causing reticuloruminal stasis.
  • Adrenergic pathways differentially modulate motility: alpha1 receptors increase contractility, while alpha2, beta1, and beta2 receptors inhibit gastric centers and motility.

Conclusions:

  • Vagal pathways and adrenergic signaling play significant roles in regulating reticuloruminal motility.
  • Bacterial endotoxins disrupt normal motility through specific intermediate effects on smooth muscle and central gastric centers.