Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Left ventricular dysfunction and cytoprotection.

L M Gonçalves1

  • 1Cardiology Department, Coimbra University Hospital Medical School, Coimbra University, Portugal. lgoncalv@ci.uc.pt

Revista Portuguesa De Cardiologia : Orgao Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
|February 24, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polymer Sorting Through Fluorescence Spectra.

Bioengineering (Basel, Switzerland)·2025
Same author

Computer vision analysis of luteal color Doppler ultrasonography for early and automated pregnancy diagnosis in Bos taurus beef cows.

Journal of animal science·2025
Same author

Design of a sensor to estimate suspended sediment transport in situ using the measurements of water velocity, suspended sediment concentration and depth.

Journal of environmental management·2024
Same author

Supplementing Ca salts of soybean oil via low-moisture molasses-based blocks to improve reproductive performance and overall productivity of beef cows.

Animal reproduction science·2023
Same author

Development of an automated sensor for in-situ continuous monitoring of streambed sediment height of a waterway.

The Science of the total environment·2021
Same author

Effectiveness of contact tracing and quarantine on reducing COVID-19 transmission: a retrospective cohort study.

Public health·2020
Same journal

What is the optimal long-term management strategy after acute myocarditis?

Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology·2026
Same journal

An expert consensus statement on renal denervation for the management of hypertension endorsed by the Portuguese Association of Interventional Cardiology of the Portuguese Society of Cardiology (APIC-SPC) and the Portuguese Society of Hypertension (SPH).

Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology·2026
Same journal

OCT-documented cutting-balloon fenestration of intramural hematoma in right coronary artery dissection.

Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology·2026
Same journal

Multimodality imaging for cardiac metastatic squamous cell carcinoma of unknown primary.

Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology·2026
Same journal

Lactoferrin: a new ally in mitigating anthracycline cardiotoxicity?

Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology·2026
Same journal

The ascending aorta in bicuspid aortic valves - The bad guy?

Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology·2026
See all related articles

Heart failure worsens due to myocyte apoptosis, a process triggered by various factors. Therapies targeting these triggers and preserving mitochondrial function may protect heart cells and reduce heart failure progression.

Area of Science:

  • Cardiovascular Research
  • Cellular Biology
  • Pathophysiology

Background:

  • Heart failure is a growing concern due to population aging.
  • Myocyte apoptosis significantly contributes to heart failure progression.
  • Understanding apoptosis triggers is crucial for developing effective treatments.

Purpose of the Study:

  • To explore the mechanisms of myocyte apoptosis in heart failure.
  • To identify potential therapeutic targets for cytoprotection.
  • To highlight the role of mitochondria in myocyte viability.

Main Methods:

  • Review of existing knowledge on heart failure pathophysiology.
  • Analysis of apoptosis-inducing factors (e.g., adrenergic stimulation, angiotensin II).
  • Examination of the role of mitochondrial function in myocyte survival.

Related Experiment Videos

Main Results:

  • Myocyte apoptosis leads to a decrease in cardiac myocytes, worsening heart failure.
  • Apoptosis can be initiated by adrenergic stimulation, angiotensin II, and metabolic changes.
  • Mitochondrial dysfunction severely compromises myocyte viability.

Conclusions:

  • Inhibiting apoptosis triggers with drugs like beta-blockers or ACE inhibitors may offer cytoprotection.
  • Therapies that prevent mitochondrial dysfunction are vital for cytoprotection in heart failure.
  • Targeting apoptosis and mitochondrial health presents a promising strategy for heart failure management.