Related Experiment Video
Updated: Aug 7, 2026

Correlative Light- and Electron Microscopy Using Quantum Dot Nanoparticles
Published on: August 7, 2016
The continuing value of electron microscopy in surgical pathology
1Department of Pathology, University of South Alabama, Mobile 36617, USA.
Transmission electron microscopy (TEM) remains crucial for diagnosing specific surgical pathology cases and certain neoplasms. While complementary to immunohistochemistry, TEM
Area of Science:
- Surgical Pathology
- Diagnostic Imaging
- Microscopy Techniques
Background:
- Transmission electron microscopy (TEM) has a long-standing diagnostic role in surgical pathology.
- Advances in immunohistochemistry (IHC) and other techniques raise questions about TEM's continued importance.
- TEM offers educational value and research applicability beyond diagnostics.
Purpose of the Study:
- To evaluate the current diagnostic utility of TEM in surgical pathology.
- To address the controversy surrounding TEM's role in neoplasm evaluation.
- To determine if TEM is complementary or competitive with IHC.
Main Methods:
- Review of diagnostic applications of TEM in surgical pathology.
- Analysis of expert opinions on TEM's role in neoplasm diagnosis.
- Comparison of TEM with IHC in specific pathological contexts.
Main Results:
- TEM is essential for specific cases like renal biopsies and cilia specimens.
- Expert consensus suggests TEM is vital for diagnosing certain neoplasms.
- TEM and IHC are most powerful when used as complementary techniques.
Conclusions:
- TEM remains an essential diagnostic tool in surgical pathology when optimally applied.
- Effective consultation by electron microscopists is key to maximizing TEM's potential.
- TEM's complementary role alongside IHC enhances diagnostic accuracy for select conditions.
More Related Videos
11:19Multimodal Hierarchical Imaging of Serial Sections for Finding Specific Cellular Targets within Large Volumes
Published on: March 20, 2018
06:47Expanding the Comprehension of the Tumor Microenvironment using Mass Spectrometry Imaging of Formalin-Fixed and Paraffin-Embedded Tissue Samples
Published on: June 29, 2022
Related Concept Videos
Overview of Electron Microscopy
Scanning Electron Microscopy
Fundamental Principles
Accelerated...
Preparation of Samples for Electron Microscopy
Overview of Microscopy Techniques
Two-Dimensional Microscopy in Microbiology
Three-Dimensional Microscopy in Microbiology