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Design and synthesis of sialyl Lewis x mimics as E-selectin inhibitors

N Kaila1, B E Thomas, P Thakker

  • 1Department of Chemical Sciences, Wyeth Research, Cambridge, MA 02140, USA. nkaila@genetics.com

Bioorganic & Medicinal Chemistry Letters
|February 24, 2001
PubMed

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Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...