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Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding
Published on: September 16, 2010
3,28-Di-O-(dimethylsuccinyl)-betulin isomers as anti-HIV agents
Y Kashiwada1, J Chiyo, Y Ikeshiro
1Niigata College of Pharmacy, Japan. kasiwada@niigata-pharm.ac.jp
Bioorganic & Medicinal Chemistry Letters
|February 24, 2001
Abstract:
Four isomers of 3,28-di-O-(dimethylsuccinyl)-betulin were prepared and evaluated for anti-HIV activity against HIV-1 replication in H9 lymphocyte cells. 3-O-(3',3'-Dimethylsuccinyl)-28-O-(2", 2"-dimethvlsuccinyl)-betulin (11) was the most potent anti-HIV compound with an EC5, value of 0.00087 microM and a TI value of 42,400.
