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The discovery of anthranilic acid-based MMP inhibitors. Part 1: SAR of the 3-position

J I Levin1, M T Du, J F DiJoseph

  • 1Wyeth-Ayerst Research, Pearl River, NY 10965, USA. levinji@war.wyeth.com

Bioorganic & Medicinal Chemistry Letters
|February 24, 2001
PubMed

Abstract:

A novel series of anthranilic acid-based inhibitors of MMP-1, MMP-9, and MMP-13 was prepared and evaluated both in vitro and in vivo. The most potent compound, 6e, has in vivo activity in a rat sponge-wrapped cartilage model.

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