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Cocaine catalytic antibodies: the primary importance of linker effects
M Matsushita1, T Z Hoffman, J A Ashley
1The Scripps Research Institute and the Skaggs Institute for Chemical Biology, Department of Chemistry, La Jolla, CA 92037, USA.
Bioorganic & Medicinal Chemistry Letters
|February 24, 2001
Abstract:
Current treatments for cocaine addiction are not effective. The development of a catalytic monoclonal antibody (mAb) provides a strategy for not only binding, but also degrading cocaine, which offers a broad-based therapy. Hapten design is the central element for programming antibody catalysis. The characteristics of the linker used in classic transition-state analogue phosphonate haptens were shown to be important for obtaining mAbs that hydrolyze the benzoate ester of cocaine.