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Updated: Aug 17, 2026

Assessment of Dopaminergic Homeostasis in Mice by Use of High-performance Liquid Chromatography Analysis and Synaptosomal Dopamine Uptake
Published on: September 21, 2017
Altered striatal dopamine D2 receptor density and dopamine transport in a patient with hepatic encephalopathy
K Weissenborn1, G Berding, H Köstler
1Department of Neurology, Medizinische, Hochschule Hannover, Germany. Weissenborn.Karin@mh-hannover.de
Abstract:
A patient suffering from liver cirrhosis presented with a bradykinetic-rigid syndrome suspected as Parkinson's disease. A detailed work-up of the case revealed hepatic encephalopathy as the cause of the neurological symptomatology. An alteration of striatal dopamine D2 receptor binding and dopamine re-uptake sites was demonstrated by 123I-iodobenzamide (IBZM) and 123I-beta-CIT single photon emission computed tomography (SPECT), respectively. It is suggested that the alteration of the dopamine re-uptake in cirrhotics may be the cause of an increased catabolism of dopamine in HE.
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