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Switching clozapine responders to olanzapine
K H Littrell1, C G Johnson, N M Hilligoss
1Promedica Research Center, Tucker, GA 30084, USA. promedica@aol.com
The Journal of Clinical Psychiatry
|February 24, 2001
Summary
Converting from clozapine to olanzapine in schizophrenia patients maintained symptom control while reducing adverse effects. This switch offers a viable option for those experiencing clozapine-induced side effects.
Area of Science:
- Psychiatry
- Pharmacology
- Clinical Neuroscience
Background:
- Clozapine is an atypical antipsychotic for treatment-resistant schizophrenia.
- Clozapine use is limited by risks of agranulocytosis, seizures, sedation, and weight gain.
- Adverse effects often necessitate alternative treatments for clozapine responders.
Purpose of the Study:
- To evaluate the efficacy and safety of slow cross-titration from clozapine to olanzapine.
- To assess outcomes in clozapine-responsive patients experiencing medication-induced adverse events.
Main Methods:
- 20 outpatients with schizophrenia or schizoaffective disorder were converted from clozapine to olanzapine.
- Patients were clozapine-responsive but sought alternatives due to side effects.
- Symptomatology, mood, subjective response, and safety were monitored.
Main Results:
- Olanzapine demonstrated equivalent efficacy to clozapine in 90% of patients.
- No rehospitalizations or suicidal behavior were observed post-conversion.
- A reduction in drug-induced side effects and improved subjective response were noted.
Conclusions:
- Successful conversion from clozapine to olanzapine can reduce side effects while maintaining symptom control.
- This strategy offers significant patient benefits.
- Further research into clozapine-to-olanzapine conversion is warranted.
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