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Imaging In-Stent Restenosis: An Inexpensive, Reliable, and Rapid Preclinical Model
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Published on: September 14, 2009

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Acute and subacute stent occlusion; risk-reduction by ionic contrast media

B Scheller1, B Hennen, A Pohl

  • 1Division of Internal Medicine III , University of Saarland, Homburg/Saar, Germany.

European Heart Journal
|February 24, 2001
PubMed

Insights

Ionic contrast media, like Ioxaglate, significantly reduced stent thrombosis and adverse clinical events compared to non-ionic media in cardiology interventions. This finding supports Ioxaglate use when coronary stent placement is anticipated.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Biomedical Engineering

Background:

  • Controversial data exists on contrast media's impact on thrombotic complications in interventional cardiology.
  • The effect of ionic contrast media on acute and subacute stent thrombosis remains under-investigated.

Purpose of the Study:

  • To investigate the influence of ionic versus non-ionic contrast media on stent thrombosis.
  • To compare the incidence of acute and subacute stent occlusion between different contrast media types.

Main Methods:

  • A study involving 3,990 patients undergoing coronary stent placement.
  • Group I (1808 patients) received non-ionic contrast media; Group II (2182 patients) received ionic Ioxaglate.
  • All patients received aspirin and ticlopidine for 4 weeks post-intervention.

Main Results:

  • Acute stent occlusion was higher with non-ionic media (1.3%) versus ionic Ioxaglate (0.3%), P=0.001.
  • Subacute stent occlusion was also higher with non-ionic media (2.4%) versus ionic Ioxaglate (0.7%), P=0.001.
  • Ioxaglate use significantly reduced the combined endpoint of CABG, TLR, and mortality within 12 months (16.3% vs 22.9%, P=0.001).

Conclusions:

  • The use of ionic contrast media, specifically Ioxaglate, is associated with lower rates of stent thrombosis.
  • Ioxaglate demonstrates a significant reduction in major adverse cardiovascular events post-intervention.
  • Recommend Ioxaglate for coronary interventions involving anticipated stent placement.
Abstract

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