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Related Experiment Videos

Amphotericin B lipid complex for neonatal invasive candidiasis.

F Adler-Shohet1, H Waskin, J M Lieberman

  • 1Miller Children's Hospital, Long Beach, California and University of California, Irvine, California, USA.

Archives of Disease in Childhood. Fetal and Neonatal Edition
|February 24, 2001
PubMed
Summary

Amphotericin B lipid complex (ABLC) showed promising safety and efficacy in treating systemic Candida infections in 11 neonates. Most infants experienced clinical improvement and mycological cure, with stable kidney function.

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Area of Science:

  • Neonatal Medicine
  • Mycology
  • Infectious Diseases

Background:

  • Systemic Candida infections pose a significant threat to neonates.
  • Limited treatment options exist for invasive fungal infections in this vulnerable population.

Purpose of the Study:

  • To evaluate the safety and efficacy of amphotericin B lipid complex (ABLC) for treating systemic Candida infections in neonates.
  • To assess clinical improvement, mycological cure rates, and renal function in neonates receiving ABLC.

Main Methods:

  • Retrospective analysis of 11 neonates with confirmed systemic Candida infections.
  • Treatment with amphotericin B lipid complex (ABLC).
  • Monitoring of clinical status, fungal eradication, and serum creatinine levels.

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Main Results:

  • Nine out of 11 neonates showed clinical improvement.
  • Eight of nine evaluable patients achieved mycological cure.
  • Eight of 11 patients demonstrated stable or improved creatinine levels, indicating good renal safety.

Conclusions:

  • Amphotericin B lipid complex (ABLC) is a safe and effective treatment option for systemic Candida infections in neonates.
  • ABLC demonstrates favorable clinical and mycological outcomes with acceptable renal safety in this patient group.