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Depression does not influence basal ganglia-mediated psychomotor speed in HIV-1 infection
H J von Giesen1, R Bäcker, H Hefter
1Department of Neurology, Heirich Heine University, Duesseldorf, Germany. giesenhj@uni-duesseldorf.de
Abstract:
The authors examined the effects of depressive mood (Hamilton Rating Scale for Depression [Ham-D]) on basal ganglia-mediated psychomotor speed (motor test battery) in 202 HIV-1 seropositive homosexual males with no prior history of antiretroviral treatment. HIV-1 seropositive patients showed a significant slowing of most rapid alternating movements (MRAM) and significantly prolonged contraction times (CT) compared with 66 HIV-1 seronegative male control subjects. Factor analysis of Ham-D scores isolated a factor containing the items depressed mood, suicide, and psychic and somatic anxiety. This factor did not correlate with MRAM or CT. Depression and psychomotor speed are independent in HIV-1infection.