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Sphincter of Oddi dysfunction associated with choledochal cyst.
A G Craig1, L D Chen, G T Saccone
1Department of General and Digestive Surgery, Flinders Medical Center, Adelaide, Australia.
Journal of Gastroenterology and Hepatology
|February 24, 2001
Summary
Choledochal cysts may be linked to sphincter of Oddi dysfunction. This study found elevated pressures in patients with these cysts, suggesting a potential role for sphincter of Oddi dysfunction in their development.
Area of Science:
- Gastroenterology
- Hepatobiliary Surgery
- Surgical Physiology
Background:
- The exact cause of choledochal cysts is not fully understood.
- Anomalous pancreato-biliary junction and pancreatic enzyme reflux are known contributing factors.
Observation:
- Sphincter of Oddi (SO) manometry was conducted in three choledochal cyst patients.
- All patients presented with elevated basal pressure, indicating SO dysfunction.
Findings:
- Two patients also had APBJ.
- A correlation between choledochal cysts and SO dysfunction was observed.
Implications:
- SO dysfunction may contribute to the development of choledochal cysts.
- Further research into the role of SO dysfunction in biliary pathologies is warranted.