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Estimation of antithyroid antibodies occurrence in children with coeliac disease
E Kowalska1, K Wasowska-Królikowska, E Toporowska-Kowalska
1Department of Gastroenterology and Paediatric Allergology, Institute of Paediatrics, Medical University, ul. Spoma 36/50, 91-738 Łódź, Poland.
Introduction:
The coexistence of coeliac disease (CD) and the diseases of autoimmune origin is often discussed in literature. In this study the evaluation of antithyroid antibodies (antimicrosomal-TMA, anti-thyreoglobulin-ATG, thyroid peroxidase antibodies anti-TPO) occurrence against clinical and laboratory determinants of thyroid function is demonstrated in children with coeliac disease.
Material And Methods:
The study was conducted on 34 IgA-EmA positive children; control group consisted of 28 children with negative screening tests for coeliac disease.
Results:
In both groups, the level of antithyroid antibodies (TMA, ATG, anti-TPO) and determinants of thyroid gland function (TSH, fT3, fT4) were evaluated; USG examination of thyroid gland was also performed. Elevated titres of antithyroid antibodies observed in children with coeliac disease (41.1%) in comparison to control group (3.56%) indicate the need for performing the screening tests for antithyroid antibodies in children with CD.
