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Published on: October 12, 2017
Postheparin serum lipolytic activity in psoriatic males
A Pietrzak1, B Lecewicz-Toruń, A Borzecki
1Department of Dermatology, Medical University, ul. Radziwillowska 13, 20-080 Lublin, Poland.
Summary
Psoriatic males exhibit altered lipid metabolism, with higher triglyceride, glycerol, and free fatty acid levels. Postheparin lipolysis is significantly changed in psoriatic individuals compared to healthy controls.
Area of Science:
- Biochemistry
- Dermatology
- Metabolic Research
Background:
- Psoriasis is associated with disturbances in blood lipid composition and lipolytic enzyme activity.
- Investigating postheparin lipolytic activity in psoriatic males is crucial for understanding lipid metabolism in this population.
Purpose of the Study:
- To investigate the postheparin lipolytic activity in the serum of psoriatic males.
- To compare lipid metabolism and lipolysis response to heparin in psoriatic males versus healthy controls.
Main Methods:
- Serum samples from 30 psoriatic males and 35 healthy males were analyzed.
- Concentrations of triglycerides (TG), free fatty acids (FFA), and glycerol (G) were measured before and 30 minutes after intravenous heparin injection.
- Lipolytic process was assessed by observing the release of glycerol and FFA and the reduction of TG.
Main Results:
- Psoriatic sera showed higher concentrations of triglycerides, glycerol, and free fatty acids both before and after lipolysis compared to controls.
- The course of postheparin lipolysis in psoriatic males appeared altered compared to the healthy control group.
Conclusions:
- Psoriasis is associated with significant alterations in serum lipid concentrations and postheparin lipolytic activity.
- These findings suggest a dysregulated lipid metabolism in psoriatic males, warranting further investigation into the underlying mechanisms and clinical implications.
