Is TT virus (transfusion transmitted virus) a novel hepatotropic agent causing hepatitis?

Area of Science:

• Virology
• Infectious Diseases
• Public Health

Background:

• The Transfusion-Transmitted Virus (TTV) was first identified in Japan in 1997.
• TTV is a non-enveloped DNA virus belonging to the Anelloviridae family.
• Its discovery prompted investigations into its global prevalence and clinical significance.

Purpose of the Study:

• To provide a comprehensive review of the existing world literature on TT virus (TTV) infections.
• To synthesize current knowledge regarding the epidemiology, transmission, and clinical impact of TTV.
• To identify gaps in research and areas for future investigation concerning TTV.

Main Methods:

• Systematic literature search of major scientific databases (e.g., PubMed, Scopus).
• Inclusion of studies published in peer-reviewed journals focusing on TTV detection and characterization.
• Analysis and synthesis of data related to TTV prevalence, transmission routes, and associated health outcomes.

Main Results:

• TTV infections have been reported across diverse geographical regions worldwide.
• Evidence suggests various transmission routes, including transfusion, sexual contact, and vertical transmission.
• The clinical significance of TTV infection remains largely undetermined, with associations to some liver diseases but often found in healthy individuals.

Conclusions:

• TTV is a globally distributed virus with a complex transmission network.
• Further research is crucial to elucidate the pathogenic potential and clinical relevance of TTV infections.
• Understanding TTV epidemiology is essential for public health strategies and blood safety considerations.