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Autoantibodies associated with atherosclerosis
Y Shoenfeld1, Y Sherer, J George
1Department of Medicine B and the Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel. Shoenfel@post.tau.ac.il
Annals of Medicine
|February 24, 2001
Abstract:
Atherosclerosis is a multifactorial pathological process. In recent years, the immune factors associated with its initiation and progression have been investigated intensively. Several autoantigens and their respective autoantibodies have been suggested as factors in atherogenesis. This manuscript provides a review of autoantibodies directed towards oxidized low-density lipoprotein (oxLDL), cardiolipin, beta2-glycoprotein-I and heat-shock protein 60/65, and their association with human and murine atherosclerosis.