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St. John's Wort.

H L Field1, D A Monti, J M Greeson

  • 1Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

International Journal of Psychiatry in Medicine
|February 24, 2001
PubMed
Summary
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St. John's Wort shows potential for mild to moderate depression, but more research is needed. Current evidence on its effectiveness and safety is limited by trial quality, requiring further controlled studies.

Area of Science:

  • Herbal medicine
  • Pharmacology
  • Clinical research

Background:

  • St. John's Wort (Hypericum perforatum) is a widely used herbal remedy.
  • Its pharmacological properties and mechanisms of action are not fully elucidated.
  • Existing data primarily focuses on its application in mood disorders.

Purpose of the Study:

  • To review current knowledge on the pharmacology of St. John's Wort.
  • To examine its sites of action and therapeutic effectiveness.
  • To assess its efficacy and safety profile.

Main Methods:

  • Comprehensive literature review utilizing Medline database searches.
  • Inclusion of relevant studies identified through bibliographical searches.
  • Critical appraisal of available research on St. John's Wort.

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Main Results:

  • Most data pertains to St. John's Wort for mild to moderate depression, with mixed but often positive opinions.
  • Significant variability in the quality of therapeutic trials prevents definitive conclusions.
  • Preliminary reports suggest potential in other conditions like infections and malignancies, but require further investigation.

Conclusions:

  • Further high-quality, controlled studies are essential to establish the effectiveness, safety, and mechanism of action of St. John's Wort.
  • Current evidence is insufficient to draw firm conclusions regarding its therapeutic benefits.
  • Exploration of St. John's Wort for non-depressive conditions is in its nascent stages.