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Fluid loading in rats increases serum brain natriuretic peptide concentration
S Inoha1, T Inamura, A Nakamizo
1Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582 Fukuoka, Japan. s-inoha@ns.med.kyushu-u.ac.jp
Neurological Research
|February 24, 2001
Summary
Volume expansion therapy, often used after subarachnoid hemorrhage, significantly increases brain natriuretic peptide levels. This suggests hypervolemic therapy may contribute to elevated brain natriuretic peptide concentrations in patients.
Area of Science:
- Neuroscience
- Endocrinology
- Nephrology
Background:
- Hyponatremia following subarachnoid hemorrhage (SAH) is associated with elevated atrial natriuretic peptide and brain natriuretic peptide (BNP) levels.
- Volume expansion therapies, including hypertensive and hypervolemic therapy, are used to prevent vasospasm after SAH and may influence natriuretic peptide concentrations.
Purpose of the Study:
- To investigate the effect of acute volume expansion on brain natriuretic peptide (BNP) secretion in a rat model.
- To determine if hypervolemic therapy contributes to elevated plasma BNP concentrations observed after SAH.
Main Methods:
- Rats underwent acute volume expansion by infusing 10 ml of saline over 1 hour.
- Plasma BNP concentrations were measured before infusion and at 1 and 2 hours after initiation of infusion.
Main Results:
- A significant increase in plasma BNP concentrations was observed 1 hour after initiating saline infusion in the 10 ml group.
- BNP levels began to decrease by 2 hours post-infusion, although they remained elevated compared to baseline.
Conclusions:
- Acute volume expansion stimulates BNP secretion.
- Hypervolemic therapy may be a contributing factor to the elevated plasma BNP concentrations seen in patients with subarachnoid hemorrhage.