Can gene therapy overcome the problem of hypoxia in radiotherapy?

Toward a high-throughput screening platform for directed evolution of enzymes that activate genotoxic prodrugs.

Protein engineering, design & selection : PEDS·2014

Targeted mutagenesis of the Vibrio fischeri flavin reductase FRase I to improve activation of the anticancer prodrug CB1954.

Biochemical pharmacology·2012

Association of angiopoietin-2, C-reactive protein and markers of obesity and insulin resistance with survival outcome in colorectal cancer.

British journal of cancer·2010

uvrB gene deletion enhances SOS chromotest sensitivity for nitroreductases that preferentially generate the 4-hydroxylamine metabolite of the anti-cancer prodrug CB1954.

Journal of biotechnology·2010

In vivo characterization of horseradish peroxidase with indole-3-acetic acid and 5-bromoindole-3-acetic acid for gene therapy of cancer.

Cancer gene therapy·2010

Discovery and evaluation of Escherichia coli nitroreductases that activate the anti-cancer prodrug CB1954.

Biochemical pharmacology·2009

Urinary tritium concentrations and associated environmental factors among residents living near a nuclear power plant in South Korea: a community-based biomonitoring study.

Journal of radiation research·2026

Radiation-induced tumor following pencil beam scanning proton therapy for pediatric intracranial ependymoma: a pragmatic analysis of risk factors.

Journal of radiation research·2026

A patch-based bolus technique for total scalp irradiation: dosimetric impact of conformity and reproducibility.

Journal of radiation research·2026

LINAC-based single-isocenter stereotactic radiotherapy for multiple brain metastases.

Journal of radiation research·2026

Utility of 2-[18F]Fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography in assessing treatment response after chemoradiotherapy for cervical cancer.

Journal of radiation research·2026

Dosimetric feasibility of carbon-ion radiotherapy for ocular melanomas with local effect model-based treatment planning system.

Journal of radiation research·2026

Protective Effects of Fushiming Against Microwave Radiation-Induced Retinal Damage: A Network Pharmacology and Experimental Study.

Current eye research·2026

C7 Vertebral Pathological Compressive Fracture after Radiotherapy for Esophageal Cancer: A Case Report.

NMC case report journal·2026

Multi-Sequence Fusion MRI Deep Learning Models for Discrimination of Recurrent Nasopharyngeal Carcinoma and Osteoradionecrosis.

World journal of otorhinolaryngology - head and neck surgery·2026

Disseminated Nocardia farcinica Infection Presenting as Multiple Intramuscular Abscesses Mimicking Skeletal Muscle Metastases in a Patient With Hepatocellular Carcinoma.

Cureus·2026

Related Experiment Videos

Can gene therapy overcome the problem of hypoxia in radiotherapy?

Related Concept Videos

Toward a high-throughput screening platform for directed evolution of enzymes that activate genotoxic prodrugs.

Targeted mutagenesis of the Vibrio fischeri flavin reductase FRase I to improve activation of the anticancer prodrug CB1954.

Association of angiopoietin-2, C-reactive protein and markers of obesity and insulin resistance with survival outcome in colorectal cancer.

uvrB gene deletion enhances SOS chromotest sensitivity for nitroreductases that preferentially generate the 4-hydroxylamine metabolite of the anti-cancer prodrug CB1954.

In vivo characterization of horseradish peroxidase with indole-3-acetic acid and 5-bromoindole-3-acetic acid for gene therapy of cancer.

Discovery and evaluation of Escherichia coli nitroreductases that activate the anti-cancer prodrug CB1954.

Urinary tritium concentrations and associated environmental factors among residents living near a nuclear power plant in South Korea: a community-based biomonitoring study.

Radiation-induced tumor following pencil beam scanning proton therapy for pediatric intracranial ependymoma: a pragmatic analysis of risk factors.

A patch-based bolus technique for total scalp irradiation: dosimetric impact of conformity and reproducibility.

LINAC-based single-isocenter stereotactic radiotherapy for multiple brain metastases.

Utility of 2-[18F]Fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography in assessing treatment response after chemoradiotherapy for cervical cancer.

Dosimetric feasibility of carbon-ion radiotherapy for ocular melanomas with local effect model-based treatment planning system.

Protective Effects of Fushiming Against Microwave Radiation-Induced Retinal Damage: A Network Pharmacology and Experimental Study.

C7 Vertebral Pathological Compressive Fracture after Radiotherapy for Esophageal Cancer: A Case Report.

Multi-Sequence Fusion MRI Deep Learning Models for Discrimination of Recurrent Nasopharyngeal Carcinoma and Osteoradionecrosis.

Disseminated Nocardia farcinica Infection Presenting as Multiple Intramuscular Abscesses Mimicking Skeletal Muscle Metastases in a Patient With Hepatocellular Carcinoma.

Related Experiment Videos

Can gene therapy overcome the problem of hypoxia in radiotherapy?

Related Concept Videos

Related Articles