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[Evaluation of antibiotic preparations for children from a standpoint of water-solubilities]

Y Honda1, M Nakano

  • 1Department of Pharmacy, Kumamoto University Hospital, Honjo 1-1-1, Kumamoto 860-8556, Japan.

The Japanese Journal of Antibiotics
|February 24, 2001
PubMed

Insights

Water-solubility varies significantly among pediatric antibiotic preparations. This study categorizes antibiotics like cefaclor (CCL) and faropenem sodium (FRPM) into three groups based on their solubility, suggesting dosage-form standardization.

Area of Science:

  • Pharmaceutical Sciences
  • Drug Formulation
  • Pediatric Pharmacology

Context:

  • Antibiotic preparations for pediatric use are widely prescribed.
  • Variability in drug solubility can impact therapeutic efficacy and administration.
  • Current dosage-form classifications may not fully reflect solubility characteristics.

Purpose:

  • To evaluate the water-solubility of seven common pediatric antibiotic preparations.
  • To assess solubility of both the final preparation and the active pharmaceutical ingredient.
  • To propose a classification system for pediatric antibiotic dosage forms based on solubility.

Summary:

  • Seven pediatric antibiotics (cefaclor, cefpodoxime proxetil, cefdinir, cefditoren pivoxil, cefcapene pivoxil, clarithromycin, faropenem sodium) were tested for water-solubility.
  • Significant differences in solubility were observed, ranging from 40% to 100% for preparations and nearly 0% to 100% for component drugs.
  • Antibiotics were categorized into three groups: suitable for solution/suspension, suitable for suspension, and fine granules unsuitable for suspension.

Impact:

  • Highlights the need for standardized nomenclature for pediatric antibiotic dosage forms.
  • Informs healthcare providers about potential formulation differences affecting drug delivery.
  • Guides pharmaceutical development towards more predictable and administrable pediatric formulations.

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