[The effect of adding cefobid upon the physiochemical properties of calcium phosphate cement]

This study was conducted to analyze the physiochemical properties of different mass ratio compounds of cefobid-load calcium phosphate cement(CPC). The compounds of 0%, 2.9%, 4.8% and 7.4% mass ratio cefobid-load CPC were made respectively. The setting time was observed; the compressive strength of compounds was measured by a material testing machine; the construction of compounds was observed by scanning electron microscopy(SEM) and analyzed by EIG. The results showed that both the setting time and the ratio of hole did not change obviously after the addition of cefobid, but the ultimate compressive strength decreased slowly and the results of the four groups were (21.98 +/- 1.06)MPa, (21.38 +/- 0.95)MPa, (19.22 +/- 1.11)MPa and (13.5 +/- 1.65)MPa respectively. These data indicate there is no obvious effect on the physicochemical properties of calcium phosphate cement after the addition of cefobid between 0% and 4.8%. The compounds have irregular holes and hence a good ability of compressive strength. It might be a new bone grafting material for the reparation of infection-related bone defects.