Left ventricular hypertrophy is associated with an attenuated endothelium-dependent vasodilation in hypertensive men

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J Millgård1, A Hägg, T Kahan

  • 1Department of Internal Medicine, University Hospital of Uppsala, Sweden.

Blood Pressure
|February 24, 2001
PubMed

Insights

Left ventricular hypertrophy (LVH) is linked to impaired endothelium-dependent vasodilation (EDV) in hypertensive patients. This suggests endothelial dysfunction may contribute to LVH development or indicate a more severe hypertensive condition.

Area of Science:

  • Cardiology
  • Vascular Biology
  • Hypertension Research

Background:

  • Left ventricular hypertrophy (LVH) is a common complication of hypertension.
  • Endothelial dysfunction, characterized by impaired vasodilation, is increasingly recognized in hypertensive individuals.
  • The relationship between LVH and endothelial function requires further elucidation.

Purpose of the Study:

  • To investigate the association between left ventricular hypertrophy (LVH) and endothelium-dependent vasodilation (EDV) in hypertensive patients.
  • To compare EDV and endothelium-independent vasodilation (EIDV) in hypertensive patients with and without LVH, and with healthy controls.

Main Methods:

  • Evaluated 30 untreated hypertensive, 18 treated hypertensive, and 26 normotensive control subjects.
  • Assessed forearm EDV using methacholine (MCh) infusion and EIDV using sodium nitroprusside (SNP) infusion.
  • Measured forearm blood flow via plethysmography and LVH via echocardiography.

Main Results:

  • Hypertensive patients with LVH exhibited significantly reduced EDV compared to those without LVH, in both untreated and treated groups.
  • EDV was significantly impaired in hypertensive patients with LVH compared to healthy controls.
  • No significant differences in EIDV were observed between groups.

Conclusions:

  • The presence of LVH in hypertensive patients is associated with endothelial dysfunction.
  • Endothelial dysfunction may play a role in the development of LVH.
  • LVH and endothelial dysfunction may serve as co-markers of more severe hypertensive disease.

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