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General synthesis of alpha-substituted 3-bisaryloxy propionic acid derivatives as specific MMP inhibitors
A M Chollet1, T Le Diguarher, L Murray
1Institut de Recherches Servier, Croissy sur Seine, France.
Bioorganic & Medicinal Chemistry Letters
|February 24, 2001
Abstract:
Modulations of alpha and aryl substitutions on 3-aryloxy propionic acid hydroxamates led to novel and potent inhibitors of MMP-2,3,9 and 13, and selectivity versus MMP-1.