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Updated: Jul 8, 2026
10:20
Automation of a Positron-emission Tomography (PET) Radiotracer Synthesis Protocol for Clinical Production
Published on: October 26, 2018
The development of a potential single photon emission computed tomography (SPECT) imaging agent for the
X Tian1, L W Hsin, E L Webster
1Laboratory of Medicinal Chemistry, NIDDK, NIH, Bethesda, MD 20892, USA.
Bioorganic & Medicinal Chemistry Letters
|February 24, 2001
Abstract:
A high-affinity radioligand for CRHR1 has been prepared that can serve as a template for the development of SPECT imaging agents. The 5-chloro-N-cyclopropylmethyl-N-(2,6-dichloro-4-iodophenyl)-2-methyl-N-propylpyrimidine-4,6-diamine (6b, Ki = 14 nM), and the corresponding 4-bromophenyl analogue (6a, Ki = 21 nM), were synthesized in four steps from compound 3.
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