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Anthraquinone-peptides as inhibitors of AP-1 transcription factor
T Ijaz1, P Tran, K C Ruparelia
1School of Pharmacy & Pharmaceutical Sciences, De Montfort University, UK.
Bioorganic & Medicinal Chemistry Letters
|February 24, 2001
Abstract:
Peptide-1-[N-[2-succinamidylethyl]amino]anthraquinones containing five seven amino acid residues including the KCR motif important in AP-1 protein binding to DNA have been synthesised as potential transcription factor inhibitors. These anthraquinone-peptides showed DNA intercalative binding and inhibition of AP-1 protein binding to its DNA consensus sequence.