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Solid-phase synthesis of oligonucleotides containing a bipyridine ligand at the 3'-3' inversion of polarity site
A Galeone1, L Mayol, G Oliviero
1Dip. di Chimica delle Sostanze Naturali, Univ. di Napoli Federico II, Italy.
Bioorganic & Medicinal Chemistry Letters
|February 24, 2001
Abstract:
The preparation of a solid support useful for the synthesis of oligonucleotides with a 3'-3' inversion of polarity, via a linker containing a chelating molecule, namely 2,2'-bipyridine, is described.