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Synthesis and antifungal activities of novel 1,3-beta-D-glucan synthase inhibitors. Part 1
K Masubuchi1, T Okada, M Kohchi
1Department of Chemistry, Nippon Roche Research Center, Kanagawa, Japan.
Bioorganic & Medicinal Chemistry Letters
|February 24, 2001
Abstract:
Highly potent 1,3-beta-D-glucan synthase inhibitors 10, 11 and 13 have been identified by the chemical modification of the fungicidal macrocyclic lipopeptidolactone, RO-09-3655 (1), isolated from the cultured broth of Deuteromycotinia spp. D-Ornithine derivative (10) showed improved antifungal activity in the systemic candidiasis model in mice and reduced hepatotoxicity in vitro, as compared with 1.