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Related Experiment Videos

Hyperthermia in oncology.

M H Falk1, R D Issels

  • 1Medizinische Klinik III, Klinikum Grosshadern, Munich, Germany.

International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
|February 24, 2001
PubMed
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Hyperthermia, an increase in tissue temperature, is increasingly used with radiation and chemotherapy to treat various cancers. This multimodal approach shows promise for improving tumor control and survival rates in patients with advanced or high-risk diseases.

Area of Science:

  • Oncology
  • Medical Physics

Background:

  • Hyperthermia involves elevating tissue temperatures (40-44°C) as part of multimodal anti-cancer strategies.
  • Technical advancements have improved the clinical application of hyperthermia for both superficial and deep-seated tumors.

Purpose of the Study:

  • To review the current clinical applications of hyperthermia combined with conventional treatments for malignant diseases.
  • To assess the efficacy of hyperthermia in multimodal cancer therapy.

Main Methods:

  • Review of 33 clinical trials (17 Phase I/II, 16 Phase III) involving over 2200 patients.
  • Analysis of trials combining hyperthermia with radiotherapy, chemotherapy, or both.
  • Inclusion of studies on various solid tumors in adult and pediatric patients.

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Main Results:

  • A scientific basis supports the combined use of hyperthermia with radiation and/or chemotherapy.
  • Hyperthermia is gaining clinical acceptance due to improved technical delivery.
  • Ongoing Phase II/III trials are investigating its role in enhancing tumor control and survival.

Conclusions:

  • Hyperthermia is a valuable addition to conventional cancer treatments like radiotherapy and chemotherapy.
  • The combination therapy is particularly promising for improving outcomes in high-risk or advanced cancers.
  • Further clinical research is ongoing to optimize its use in diverse oncological settings.