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Effects of sodium diethyldithiocarbamate on type II pulmonary epithelial cells in vitro

E Tátrai1, Z Kováciková, G Karácsony

  • 1National Institute of Occupational Health, Budapest, Hungary. tatray@elender.hu

Journal of Toxicology and Environmental Health. Part A
|February 24, 2001
PubMed

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Emphysema, a major phenotype of chronic obstructive pulmonary disease (COPD), is characterized by irreversible destruction of alveolar walls and permanent enlargement of distal airspaces. Unlike chronic bronchitis, which primarily affects the airways, emphysema predominantly involves the lung parenchyma, where structural damage leads to airflow limitation.PathophysiologyIt most commonly results from prolonged exposure to cigarette smoke and other toxic gases, particularly cigarette smoke.